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Intestine and Lower Gastrointestinal Tract

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Intestine and Lower Gastrointestinal Tract14 Nov 2023

Shifting Tides: Embracing Total Neoadjuvant Therapy for Advanced Rectal Cancer

Examining trends from 2012 to 2020, researchers unveil that over 50% of 51,407 patients with locally advanced rectal cancer received total neoadjuvant chemoradiation (TNT). Factors like age and comorbidities influenced TNT rates, with stage III patients more likely to undergo it. Notably, TNT usage increased…

Inflamm Bowel Dis14 Nov 2023

Anastomosis Matters: Kono-S Offers Edge in Reducing Recurrence in Crohn’s Disease

Delving into Crohn's disease post-ileocolic resection, this meta-analysis (17 studies, 2087 patients) compares anastomotic techniques. Endoscopic postoperative recurrence (epor) risk at ≥6 months was 37.2%. Kono-S anastomosis (17.7% cases) outshone conventional methods (81% cases), showing a lower epor incidence (24.7% vs. 42.6%). Results suggest Kono-S…

Am J Surg12 Nov 2023

Crohn’s Surgery: Mesenteric Targeting Strategies Examined

In a daring move, researchers explored the short-term aftermath of groundbreaking mesenteric-targeted techniques in Crohn's disease surgery. Among 186 patients undergoing innovative approaches like Kono-S anastomosis and extended mesenteric excision, results were surprisingly positive. Despite a slightly longer operation in the mesenteric excision and exclusion…

Ann Surg11 Nov 2023

Anterior Sacrectomy Improves Pelvic Exenteration Outcomes

Researchers compare sacrectomy approaches in pelvic exenteration for advanced pelvic malignancies. Shifting from prone sacrectomy (PS) to anterior techniques (ALS, HACS), they find ALS and HACS reduce operating time, blood loss, and complications compared to PS. HACS involves more nerve and vascular resections. Despite this,…

Ann Surg11 Nov 2023

Liver Transplant Impact on Ileal Pouch Outcomes in PSC-IBD

For patients with primary sclerosing cholangitis and inflammatory bowel disease (PSC-IBD), this study explores the influence of liver transplantation (LT) on ileal pouch-anal anastomosis (IPAA) outcomes. Among 160 patients, LT correlated with higher chronic pouchitis rates but didn't affect overall and pouch survival. Nontransplanted patients…

Inflamm Bowel Dis11 Nov 2023

Assessing Pouch Function After Ileal Pouch Anal Anastomosis: Beyond Manometry

In evaluating post-proctocolectomy patients with ileal pouch anal anastomosis (IPAA), anopouch manometry (APM) highlights defecatory symptoms. Less than 10% of symptomatic IPAA patients undergo APM. Dyssynergic defecation, prevalent in 47.0% to 100% of cases, associates with fecal incontinence. APM alone proves imperfect for pouch function…

Intestine and Lower Gastrointestinal Tract10 Nov 2023

Early Discharge Proves Safe After Uncomplicated Colectomy

This retrospective study explored the relationship between postoperative discharge timing and complications in patients who underwent uncomplicated elective colectomy. Findings from over 113,000 patients revealed that early discharge (≥3 days for laparoscopic/robotic, or ≥5 days for open surgery) after minimally invasive colectomy significantly lowered the…

Ann Surg Oncol10 Nov 2023

Shifting Trends in End-of-Life Care: Where Colorectal Cancer Patients Die in the US

Researchers investigated the locations of death among colorectal cancer (CRC) patients in the United States, aiming to identify determinants and trends. From 2003 to 2019, they observed a shift from hospital and institutional settings toward home and hospice as preferred places for end-of-life care. However,…

Intestine and Lower Gastrointestinal Tract9 Nov 2023

Unveiling Factors Behind Unresolved Stomas in Rectal Cancer Surgery

This study delves into the factors contributing to the non-closure of temporary stomas following anterior resection for rectal cancer. Researchers identified several risk factors, including age over 60, advanced tumor stage, high American Society of Anesthesiologists (ASA) score, neoadjuvant chemoradiotherapy, open surgery, postoperative chemotherapy, anastomotic…