A meta-analysis of 26 studies encompassing 12,586 lesions revealed that endoscopic ultrasonography (EUS) demonstrates superior sensitivity for identifying massively submucosal invasion in early colorectal cancers compared to magnifying chromoendoscopy (MCE). Specifically, EUS had a sensitivity of 88% versus MCE’s 78%, while MCE showed greater specificity (95% versus EUS’s 87%). This distinction is critical as accurate […]
Category: Intestine and Lower Gastrointestinal Tract
Endoscopic resection offers safe alternative to colectomy.
Endoscopic techniques, including mucosal resection and submucosal dissection, provide effective treatment for dysplastic lesions in patients with inflammatory bowel disease (IBD). This retrospective analysis of 50 IBD patients revealed that endoscopic resection results in favorable short-term outcomes and organ preservation, presenting a safe alternative to colectomy. The cohort consisted of predominantly middle-aged males, with diverse […]
Initial assessments of resectability influence outcomes for colorectal cancer patients
In a study of 1,250 patients with liver-only metastatic colorectal cancer (mCRC), less than half of those initially deemed unresectable achieved successful surgical resection after systemic therapy. Factors such as younger age and better performance status correlated with the likelihood of conversion to resectability. Overall survival rates post-resection significantly exceeded those of non-resected patients across […]
Transanal and robotic surgeries yield better outcomes for rectal cancer
A Bayesian network meta-analysis of 27 randomized controlled trials involving 8,696 patients indicates that transanal robotic resection (ta-rr) and robotic resection (r-rr) demonstrate superior histopathological outcomes compared to laparoscopic resection (l-rr) for rectal cancer. Specifically, ta-rr was associated with significantly lower odds of non-complete mesorectal excision (odds ratio, 0.60). These findings contribute to ongoing debates […]
Repeat liver resection improves prognosis for colorectal liver metastasis.
Patients with recurrent colorectal liver metastases who underwent repeat liver resection experienced significantly better long-term outcomes compared to those who did not, with five-year overall survival rates of 66.3% versus 27.2% respectively. Key prognostic factors include having four or more recurrent tumors, tumors larger than 5 cm, and the presence of extrahepatic disease. Prognosis varied […]
Immune Markers Predict Tumor Spread and Recurrence in Rectal Cancer
Analysis of immune markers in healthy rectal mucosa indicates that certain cellular profiles, such as high CD8β infiltration, are significant predictors of tumor spread and recurrence in patients after transanal excision for rectal cancer. The study found strong correlations between low activation of CD8+ T cells and increased risk of lateral spread and shorter disease-free […]
Early Postoperative Recurrence Peaks at 6 Months for CRLM Patients
A study of 1,804 patients after curative resection of colorectal liver metastases revealed a median recurrence-free survival of 19.9 months, with the highest recurrence risk occurring at approximately 6 months post-surgery. The hazard curve peaked at 5.9 months, indicating a need for closer postoperative monitoring, especially in patients with high and medium tumor burdens who […]
Safe and feasible simultaneous minimal invasive resections demonstrated
A study assessing simultaneous minimally invasive resections of colorectal liver metastases and primary tumors found the procedure to be safe and feasible. Out of 281 patients, 11.7% underwent this approach, primarily affecting rectal tumors. Notably, no anastomotic leakages occurred post-resection, with complication rates remaining consistent regardless of surgical difficulty. These findings suggest that the indications […]
Emergency colorectal cancer patients in Nigeria have worse survival outcomes
Among 535 colorectal cancer patients in Nigeria, 30.7% presented emergently, often with more advanced disease. Emergency presentations were linked to significantly poorer overall survival, median survival being 6.4 months compared to 17.4 months for elective patients. Factors such as lower household income and education level were prevalent in the emergency group. Although surgery improved survival […]
Postoperative complications in colorectal cancer surgery lack uniform guidelines
A systematic review of 135 articles on postoperative complications from colorectal cancer surgery underscores significant disparities in research focus and treatment guidelines. Notably, anastomotic leakage and postoperative infections accounted for 35% and 25% of studies, while port-site metastases and cardiovascular dysfunctions received limited attention. The prevalence rates of complications varied widely, from 3% to 20%, […]