In a phase II study involving 51 patients with pilonidal sinus (PNS), RD2 Ver.02 demonstrated significant results. Three months post-treatment, 82.4% achieved primary healing, increasing to 90.2% and 82.4% at six and twelve months, respectively. Recurrence occurred in 11.8% of patients within a year, while five adverse events were reported, none severe. Thus, RD2 Ver.02 […]
Category: Intestine and Lower Gastrointestinal Tract
Preoperative iron deficiency anemia needs urgent management in CRC patients.
Preoperative iron deficiency anemia (IDA) significantly impacts colorectal cancer (CRC) patients, with up to 80% experiencing iron deficiency. This condition predisposes them to increased risk of allogeneic blood transfusion, postoperative complications, prolonged hospital stays, and higher mortality. An effective strategy for managing IDA involves using the reticulocyte hemoglobin equivalent as a diagnostic tool and administering […]
Modified Surgical Apgar Score enhances postoperative complication prediction
Modified Surgical Apgar Score (MSAS) may serve as a valuable tool in predicting postoperative complications in rectal cancer patients undergoing robotic surgery. The study analyzed 524 patients, revealing a 17.4% complication rate, with MSAS scores of 6 identified as optimal cut-off values. The area under the ROC curve was 0.740 for predicted complications, while the […]
Nomogram effectively predicts liver metastasis in colorectal cancer
A nomogram combining circulating tumor cells (CTC) from the first drainage vein and clinical parameters was developed to predict liver metastasis in colorectal cancer (CRC) patients. Analysis of data from 343 patients revealed that higher CTC levels correlated with liver metastasis. Key identified predictors included vascular invasion, T stage, carcinoembryonic antigen (CEA), and CA19-9. The […]
Functional outcomes are comparable in tatme and latme surgeries
A meta-analysis of 11 studies involving 1,020 rectal cancer patients revealed no significant differences in functional outcomes between transanal total mesorectal excision (taTME) and laparoscopic total mesorectal excision (LaTME). Measures of bowel, anorectal, and urogenital function, assessed through various scales like LARS and EORTC QLQ-C30/29, indicated similar results. These findings support the notion that both […]
Prevalence of pouch fistulas post-restorative proctocolectomy is low
A systematic review and meta-analysis of 33 studies revealed a pooled prevalence of pouch fistulas at 0.05, with pouch failure rates in fistula patients at 0.24. The prevalence of developing a pouch fistula at 3, 5, and more than 5 years was similarly low, at 0.04, 0.05, and 0.05, respectively. These findings may guide future […]
Fidaxomicin demonstrates lower recurrence rates than vancomycin.
Findings indicate that fidaxomicin and vancomycin have no significant differences in overall treatment efficacy for Clostridium difficile infection (CDI). However, fidaxomicin significantly reduced recurrence rates at 40-day (RR=0.52), 60-day (RR=0.38), and 90-day (RR=0.62) intervals compared to vancomycin. Vancomycin was shown to be more effective for severe CDI cases. In terms of long-term mortality, fidaxomicin also […]
International consensus achieved on synoptic operative report for rectal prolapse
A consensus-derived synoptic operative report for rectal prolapse surgery was developed through a Delphi process involving 176 surgeons worldwide. Out of 30 initial descriptors, 16 reached over 70% agreement, including key variables such as surgery type and mesh used. This accomplishment will standardize operative reporting, enhance clinical communication, and potentially improve quality measures in rectal […]
Small-bite fascial closure reduces hernia rates after surgery
A randomized clinical trial found that small-bite fascial closure significantly decreased the incidence of incisional hernia in open colorectal cancer surgery patients. At one year, hernia rates were 7% for the small-bite group versus 27% for the conventional group (p < 0.001). This disparity persisted into the second year (9% vs 31%, p < 0.001). […]
Sequential bundles significantly reduce surgical site infections.
In a multicentre cohort study involving 32,205 patients, two sequential preventive bundles led to a 50% reduction in surgical site infection rates, decreasing from 18.16% to 8.19%. Bundle-2 notably reduced both superficial and deep surgical site infections but was ineffective for organ/space infections in rectal surgery. Compliance with preventive measures improved with the addition of […]