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Intestine and Lower Gastrointestinal Tract

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Dis Colon Rectum4 Jun 2025

Emergency resection increases complications and mortality in colon cancer

A recent analysis of 5,056 patients with right-sided colon cancer revealed that emergency resections lead to significantly higher mortality rates (9.4% vs 4.2%) and complication rates (41.7% vs 33.0%) compared to elective resections. While anastomotic leakage rates remained statistically similar, the findings suggest that emergency…

BMC Surg3 Jun 2025

C-reactive protein-to-albumin ratio predicts chemotherapy outcomes

A multicenter study has established that a high C-reactive protein-to-albumin ratio (≥0.234) correlates with increased risk of three-year disease progression and decreased five-year survival in patients undergoing neoadjuvant chemotherapy for colorectal liver metastases. The developed clinical prediction model, incorporating the ratio, clinical risk score, and…

Int J Colorectal Dis3 Jun 2025

Higher surgical caseloads lower recurrence rates in pilonidal sinus disease

Analysis of 1,074 studies involving 130,599 patients revealed that higher annual surgical volumes significantly decrease recurrence rates for pilonidal sinus disease. Specifically, patients treated in centers performing 30 or more surgeries annually showed improved outcomes, with 5-year recurrence rates dropping to 12.5%. However, midline closure…

BJS Open2 Jun 2025

Predictive factors identified for positive circumferential resection margins

The incidence of positive circumferential resection margin (CRM) after robot-assisted total mesorectal excision (R-TME) was found to be 6.0% in a study of 1,390 patients. Significant predictors include CT4 tumors, involvement of the mesorectal fascia on MRI, and non-sphincter-saving surgeries. A predictive model demonstrated over…

Eur J Surg Oncol1 Jun 2025

Lymph node metastasis worsens survival in colorectal cancer with liver metastasis

Lymph node metastasis (LNM) significantly impacts cancer-specific survival (CSS) in colorectal cancer patients with liver metastasis (CRLM), as demonstrated in an analysis of 11,266 patients. Those with LNM exhibited poorer CSS compared to those without LNM, and this trend remained consistent across different cohorts. Incorporating…

Dig Surg1 Jun 2025

Bedside endoscopy may expedite anastomotic leakage diagnosis

A multicenter prospective study aims to evaluate a clinical pathway using routine bedside endoscopy for early detection of anastomotic leakage (AL) following colorectal surgery. Researchers hypothesize that this approach will reduce the median time for AL diagnosis from 15 to 5 days. The pathway includes…

Int J Surg31 May 2025

Seventeen lymph nodes optimally predict survival in mucinous adenocarcinoma

A multicenter study analyzed lymph node evaluations in colorectal mucinous adenocarcinoma (MAC) and established that examining at least 17 lymph nodes (ELNs) significantly correlates with improved survival rates. Data from Chinese and SEER cohorts showed a consistent median ELN count of 17, with higher counts…

Clin Transl Gastroenterol31 May 2025

Treatment adjustments significantly enhance endoscopic prognosis in Crohn’s disease

In a cohort of 199 Crohn's disease patients with postoperative anastomotic lesions, treatment adjustments yielded notable improvements in endoscopic outcomes. Specifically, strategies such as biologics switching and biologic optimization led to marked mucosal healing and ulcer improvement. Switching from non-biologics to biologics resulted in superior…

Cir Esp (Engl Ed)28 May 2025

Preoperative factors influence risk of permanent stoma after surgery

A study involving 639 rectal cancer patients identified key preoperative risk factors for permanent stoma post-sphincter-preserving surgery. Notably, 11.9% of patients developed a permanent stoma within two years. Factors such as male sex, tumor height, and the presence of synchronous liver or lung metastases were…

Ann Gastroenterol Surg28 May 2025

Identifying key signs of small bowel strangulation improves diagnosis

Findings indicate that mesenteric edema and abnormal bowel wall thickening serve as sensitive and specific indicators for both non-necrotic and necrotic small bowel strangulation (SBS). In a study involving 141 SBS patients, these indicators were significantly less frequent in cases of simple bowel obstruction. Notably,…