Osteosarcopenia, identified in 16.5% of patients, significantly increased the risk of postoperative complications after curative surgery for colorectal cancer. Patients with osteosarcopenia had lower 5-year overall survival and recurrence-free survival rates compared to those without osteosarcopenia. Multivariate analysis confirmed osteosarcopenia as an independent prognostic factor for overall and recurrence-free survival. Osteosarcopenia may serve as a […]
Category: Intestine and Lower Gastrointestinal Tract
Triple-row staple technology may reduce risk of anastomotic leak
Triple-row staple technology may reduce the risk of anastomotic leak in left-sided colorectal anastomoses. After reviewing 340 relevant citations, 6 retrospective cohort studies met inclusion. Overall, 19,372 patients had anastomoses with double-row staple technology, and 2,298 patients with triple-row staple technology. Most operations were anterior resections. Across all included studies, the risk of anastomotic leak […]
Non-Compliance with NCCN Guidelines Affects 25% of Colon Cancer Patients
Non-compliance with NCCN guidelines for colon cancer treatment affects one in four patients. Factors such as older age, female sex, black race, and tumor characteristics decrease the likelihood of guideline compliance. Conversely, higher hospital volume, specific surgical approaches, and insurance status increase compliance rates. Patient and surgeon characteristics attribute to most of the variation in […]
Conversion Surgery Reduces Mortality in Metastatic Colorectal Cancer
Conversion surgery significantly reduced mortality risk by 42% in patients with unresectable metastatic colorectal cancer treated with anti-EGFR agents and bevacizumab. Subgroup analyses showed reduced risks of mortality in patients with specific characteristics. While targeted therapy reduced mortality risk, the difference was not statistically significant between the two treatment groups. Conversion surgery may explain the […]
Interdisciplinary Laparoscopic Approach Improves Quality of Life in Women with ODS and POP
Interdisciplinary laparoscopic resection rectopexy combined with sacrocolpopexy is safe and effective for women with obstructive defecation syndrome (ODS) and pelvic organ prolapse (POP). Outcomes include significant improvement in ODS scores, bowel function, and incontinence. The approach restores pelvic floor anatomy in 80% of patients and resolves urinary incontinence in 76.5%. The study highlights the feasibility […]
Improved Surgical Planning with Liver MRI in Patients with Colorectal Liver Metastases
Liver MRI led to a 24.12% change in local treatment plans for patients eligible for surgical resection or ablation of colorectal liver metastases, based on CT findings. This study highlights the significant added value of liver MRI, particularly with contrast-enhanced imaging and diffusion-weighted sequences, in guiding preinterventional decision-making. Further large prospective studies are warranted to […]
AI Imaging Diagnosis Improves Lymph Node Metastasis Detection in Low Rectal Cancer
High-precision AI imaging methods, combining super-resolution and 3D shape data, show promising outcomes for diagnosing lymph node metastasis in low rectal cancer. In a pilot study, these methods demonstrated superior sensitivity, negative predictive value, and accuracy, offering potential as a game changer in cancer diagnosis and treatment. Although limited by a small sample size and […]
Frailty Index and Colonic Diverticular Surgery Outcomes
Use of the modified frailty index (mfi-11) showed a significant association between frail patients undergoing colonic diverticular disease surgery and increased postoperative mortality and morbidity. Findings reveal higher postoperative mortality, morbidity, longer hospital stays, and increased costs in frail individuals. The mfi-11 could serve as a valuable tool in the elective and emergent settings to […]
Cephalosporins Superior to Non-cephalosporins in Preventing SSIs in Colorectal Surgery
Meta-analysis of eight studies demonstrates that the incidence of surgical site infections (SSIs) was significantly lower in patients receiving cephalosporin antibiotics compared to non-cephalosporins after colorectal surgery (14.8% vs 25.1%). Cephalosporins may be more effective in the short term, but long-term efficacy is similar. Clinicians should consider antibiotic spectrum, pharmacokinetics, and bacterial resistance when selecting […]
Prognostic Value of Examined Lymph Node Count in CRC
Higher examined lymph node (ELN) counts (≥17) in stage III colorectal cancer (CRC) patients correlate with improved long-term survival outcomes. ELN count independently predicts overall survival, cancer-specific survival, and progression-free survival. Subgroup analysis highlights benefits in patients treated with adjuvant chemotherapy with medium to large ELN counts (≥12). Increased immune activation in the tumor microenvironment […]