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Comprehensive machine learning facilitated the identification of 12 consensus predicted genes (CPGs) linked to non-alcoholic fatty liver disease (NAFLD) following metabolic and bariatric surgery (MBS). A mouse model confirmed the mRNA expression of six hub genes—PPARA, PLIN2, MED13, INSIG1, CPT1A, and ALOX5AP—showing strong correlations with…
In adults with morbid obesity, sleeve gastrectomy (SG) significantly lowers all-cause mortality risks during follow-up compared to Roux-en-Y gastric bypass (RYGB). A systematic review and meta-analysis of 22 studies involving 333,713 patients revealed that SG is linked to reduced reoperation, reintervention, and hospitalization rates, although…
Healthcare professionals and patient representatives have reached a consensus on safe practices for bariatric and metabolic surgery tourism (BMT) in Europe. Key recommendations emphasize the importance of pre-operative evaluations, management of psychological health, and regulatory standards like surgeon accreditation. With input from 119 healthcare professionals…
Sleeve gastrectomy has shown profound benefits for metabolic health in a cohort of 199 patients, revealing significant reductions in weight, BMI, and abdominal circumference. Notable improvements in diabetic patients included decreases in fasting blood sugar and glycosylated hemoglobin levels, alongside a marked reduction in insulin…
Surgical techniques during laparoscopic sleeve gastrectomy significantly affect the development of gastroesophageal reflux disease (GERD). Analyzing 7,435 patients, the study found that using a narrower bougie size and resecting further from the pylorus increased the likelihood of requiring proton pump inhibitors (PPIs) post-surgery. Advanced age…
A systematic review and meta-analysis of 21 studies revealed that metabolic and bariatric surgeries (MBS) substantially lower cancer risk in obese patients compared to non-surgical treatments. Specifically, MBS showed protective effects against colorectal (mean effect size -.28), uterine (mean effect size -.42), breast (mean effect…
In a retrospective cohort study of 91,708 patients with metabolic dysfunction-associated steatotic liver disease and cirrhosis, bariatric surgery markedly decreased mortality risks. Those who underwent the procedure showed a 5-year overall mortality of 24.9%, compared to 37.1% in non-surgical counterparts. Significant reductions were also observed…
Implementation of the Enhanced Recovery After Surgery (ERAS) program in bariatric procedures significantly reduced hospital stay, costs, and unplanned readmissions. A study comparing pre-ERAS and post-ERAS cohorts revealed a median length of stay decrease by one day and an average cost reduction of $2,230. Additionally,…
A systematic review of 11 randomized controlled trials involving 2,323 patients indicates that both sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) show comparable hypertension remission within the first four years post-surgery. However, RYGB demonstrated a significantly greater effectiveness in achieving remission at five years…
A randomized, placebo-controlled trial demonstrated that liraglutide 3.0 mg significantly combats weight regain after Roux-en-Y gastric bypass, with 76% of subjects achieving at least a 5% total body weight loss compared to 17% in the placebo group. Notably, 21% of liraglutide recipients exceeded their postoperative…
