A novel prognostic nomogram was developed to assess cancer-specific survival (CSS) in patients with distant-metastatic hepatocellular carcinoma (dm-hcc). Using data from 651 patients, the model identified key predictors: alpha-fetoprotein levels, tumor grade, T stage, and treatment types. The nomogram achieved a c-index of 0.721 and 0.726 in training and validation sets, respectively, demonstrating strong predictive […]
Category: General Surgery
Neoadjuvant chemotherapy enhances survival rates in colon cancer
Neoadjuvant chemotherapy (NAC) has demonstrated improved five-year overall survival (81.4% versus 77.8%) and disease-free survival (79.2% versus 73.7%) in patients with locally advanced colon cancer compared to upfront surgery followed by adjuvant chemotherapy. Researchers analyzed eight randomized controlled trials involving 3,038 patients, finding NAC to result in better surgical margin outcomes without increasing surgical risks. […]
Digital cholangioscopy is safer than surgery for Mirizzi syndrome
A multicenter study comparing digital single-operator cholangioscopy (DSOC) and surgery for Mirizzi syndrome reveals that despite lower technical success rates, DSOC significantly reduces overall and severe adverse events. Among 290 patients, those undergoing DSOC exhibited fewer complications and lower rates of conversion to open surgery and need for hepaticojejunostomy. These findings suggest that DSOC is […]
Prehabilitation strategies improve outcomes in digestive cancer surgery
A recent network meta-analysis involving 2042 patients indicates that prehabilitation significantly decreases hospital stay and postoperative complications while enhancing functional recovery. Exercise-based prehabilitation outperformed other strategies for minimizing complications and improving walking distance post-surgery. Multimodal approaches also excelled in improving quality of life and alleviating depressive symptoms before surgery. Gastric cancer patients showed marked benefits […]
Apixaban reduces VTE rates compared to enoxaparin in surgery
A study investigating postoperative venous thromboembolism (VTE) prophylaxis in colorectal surgery found that patients receiving apixaban had significantly lower rates of VTE (0.16%) compared to those on enoxaparin (1.29%), with a p-value of 0.023. Despite differences in patient demographics, such as age and operative complexity, the rates of postoperative bleeding were similar between both groups. […]
Robotic-assisted laparoscopic surgery research shows rapid growth
Advancements in robotic-assisted laparoscopic surgery have fostered substantial growth in academic research, particularly after 2019. Analyzing 8,375 publications, the study reveals a surge in productivity and citation impact, with Yonsei University leading contributions. The United States remains dominant in output, while “Surgical Endoscopy” tops volume metrics. Notably, frequent keywords highlight focal areas like robotic and […]
New staging system enhances prognosis accuracy for gastric cancer
A novel prognostic staging system developed from residual tumor burden significantly outperforms the AJCC’s YpTNM staging in predicting overall survival (OS) and recurrence-free survival (RFS) in patients with locally advanced gastric cancer post-neoadjuvant chemotherapy. The study analyzed data from 537 patients, finding that factors like lymph node stage and carcinoembryonic antigen levels were robust indicators […]
Prehabilitation significantly lowers postoperative mortality and care facility discharges
A department-wide prehabilitation program notably reduced 30-day mortality, discharges to post-acute care facilities, and length of stay for high-risk surgical patients. In a study comparing prehabilitation recipients to matched historical controls, mortality decreased from 2.8% to 0.8%, and discharges to care facilities dropped from 12.9% to 8.8%. The benefits of prehabilitation differ by age, with […]
AI Revolutionizes Surgical Video Analysis in Cholecystectomy
AI algorithms were utilized to analyze 481 laparoscopic cholecystectomy videos, revealing that operative time elongated with case complexity. The study found that consultants had a longer duration of anatomy visualization compared to trainees, particularly in complex cases, with the cystic duct often identified before the cystic artery. By correlating AI-derived analytics with clinical variables, the […]
Lidocaine reduces inflammation and postoperative complications in surgery
Lidocaine, a common local anesthetic, exhibits notable anti-inflammatory and immunomodulatory effects during surgical procedures. It effectively decreases neutrophil and macrophage activation, reduces pro-inflammatory cytokines, and supports endothelial integrity. Benefits of lidocaine include reduced postoperative pain, lower opioid needs, and quicker intestinal recovery. Furthermore, preliminary findings suggest it may inhibit tumor cell migration and inflammatory pathways […]