Newsletter
Best Papers in General Surgery
The five that matter, every day.
A miRNA classifier has been developed to detect occult liver metastasis in pancreatic ductal adenocarcinoma (PDAC), revealing significant deregulation of 34 miRNAs in metastatic cases. This classifier, leveraging three key miRNAs (miR-483-5p, miR-6734-5p, and miR-548q), demonstrated high predictive efficacy in identifying metastasis, outperforming CA125 alone…
Advanced machine-learning techniques successfully identified key predictors of intestinal resection in incarcerated inguinal hernia patients, including peritonitis, intestinal obstruction, neutrophil count, C-reactive protein, and preoperative total protein. The constructed model, validated externally, demonstrated strong predictive performance with an area under the curve exceeding 0.8 for…
Lymph node metastasis (LNM) significantly impacts cancer-specific survival (CSS) in colorectal cancer patients with liver metastasis (CRLM), as demonstrated in an analysis of 11,266 patients. Those with LNM exhibited poorer CSS compared to those without LNM, and this trend remained consistent across different cohorts. Incorporating…
A multicenter prospective study aims to evaluate a clinical pathway using routine bedside endoscopy for early detection of anastomotic leakage (AL) following colorectal surgery. Researchers hypothesize that this approach will reduce the median time for AL diagnosis from 15 to 5 days. The pathway includes…
A machine learning model was developed to predict duodenal stump leakage (DSL) in 1,107 gastric cancer patients post-gastrectomy. The model utilized 189 clinical features and evaluated six algorithms, with extreme gradient boosting (XGB) achieving the highest area under the receiver operating characteristic curve (AUROC) score…
Elevated levels of extracellular vesicle (EV) MDM2-DNA in retroperitoneal liposarcoma patients suggest this biomarker could identify disease recurrence. In a study involving 42 patients, EV-MDM2 levels were significantly higher in individuals with well-differentiated or dedifferentiated liposarcoma compared to healthy controls. Post-surgery, levels dropped but rose…
In a pilot study involving 38 patients with high-risk pancreatic adenocarcinoma, diffusion-weighted MRI revealed occult liver metastases in 34.2% of cases, significantly higher than peritoneal metastases at 5.3%. With a sensitivity of 86.7% for liver metastases, it allowed avoidance of unnecessary surgical explorations in nearly…
A multicenter study analyzed lymph node evaluations in colorectal mucinous adenocarcinoma (MAC) and established that examining at least 17 lymph nodes (ELNs) significantly correlates with improved survival rates. Data from Chinese and SEER cohorts showed a consistent median ELN count of 17, with higher counts…
A study evaluating tumour pseudocapsule status using CT-based radiomics found that patients with a complete pseudocapsule showed significantly better recurrence-free survival rates than those with an incomplete pseudocapsule. Specifically, 3- and 5-year survival rates were 94.8% and 92.5% for the complete group compared to 76.7%…
In a cohort of 199 Crohn's disease patients with postoperative anastomotic lesions, treatment adjustments yielded notable improvements in endoscopic outcomes. Specifically, strategies such as biologics switching and biologic optimization led to marked mucosal healing and ulcer improvement. Switching from non-biologics to biologics resulted in superior…
