Newsletter
Best Papers in General Surgery
The five that matter, every day.
Recent advancements in immunotherapy provide new treatment avenues for advanced esophageal cancer, particularly for squamous cell carcinoma and esophagogastric adenocarcinoma. Immune checkpoint inhibitors, such as nivolumab and pembrolizumab, are now approved in various treatment settings, including adjuvant therapy for patients post-surgery and first-line treatments combined…
A machine learning model successfully predicted textbook outcomes in liver surgery using preoperative data from over 2,000 patients. The top-performing xgboost model achieved an area under the curve of 0.73. Significant predictors included minimally invasive techniques and patient characteristics such as lower comorbidity scores. Furthermore,…
Estrogen receptor-α ablation has been shown to reverse muscle fibrosis and prevent inguinal hernias, conditions affecting about 50% of men by age 75. Using a humanized mouse model, findings reveal how esr1 drives fibroblast proliferation and extracellular matrix deposition linked to hernia formation. Furthermore, pharmacological…
A study evaluated machine learning algorithms to predict discharge against medical advice for 48,394 injured inpatients over five years. Among these individuals, 8.8% opted for discharge against medical advice. The light gradient boosting machine combined with edited nearest neighbors outperformed traditional logistic regression, achieving areas…
Enhanced total extraperitoneal repair (ETEP) was compared with intraperitoneal onlay mesh repair-plus (IPOM+) for midline ventral hernia repair in a randomized trial involving 48 patients. Results indicated that ETEP had significantly longer operative times but resulted in notably lower pain scores at 6 and 24…
A study on pancreatic ductal adenocarcinoma reveals that conditional survival analysis based on kallikrein-related peptidase 7 (klk7) expression can significantly improve prognostic assessments. Results show that 1-, 2-, and 3-year conditional survival rates increased from 50.4% to 91.2%, while overall survival rates dropped from 81.9%…
A scoping review assessed 24 studies on mindfulness-based interventions (MBIs) for surgeons, revealing that such programs are feasible and significantly improve mindfulness, reduce burnout, and enhance overall well-being. Notably, these interventions also boost executive function, surgical skills, and communication. Evidence was drawn from various study…
Dynamic changes in serum AST and ALT levels after liver resection for hepatocellular carcinoma were shown to significantly impact postoperative morbidity. In a study involving 759 patients, an increase in the combined assessment of AST and ALT (caa) to ≥5 was strongly linked to higher…
A multicenter trial revealed that spray coagulation mode endoscopic submucosal dissection (scm-esd) significantly improved completion rates for treating early gastric neoplasms without the use of hemostatic forceps, achieving 83.1% versus 13.8% for conventional forced coagulation mode (fcm-esd). Procedure time and adverse event rates were comparable…
A systematic review and meta-analysis evaluated textbook outcomes (TOs) in hepatopancreaticobiliary (HPB) surgery across 27 studies involving 517,304 patients. It revealed a median TO achievement rate of 62% for hepatic procedures, 54% for biliary, and lower rates for pancreatic and liver transplantation surgeries. Importantly, achieving…
