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Best Papers in General Surgery
The five that matter, every day.
Current strategies in immunotherapy for gastrointestinal cancers include immune checkpoint inhibitors, cytokine therapies, and novel approaches like CAR-T therapy. Clinical trials demonstrate significant benefits, although challenges such as immunosuppression and adverse effects remain. Future directions emphasize overcoming barriers, improving patient selection, and developing new treatments,…
A novel prognostic model utilizing pathological signatures effectively predicts postoperative recurrence risk and sorafenib response in hepatocellular carcinoma (HCC) patients. Analyzed across 287 non-treated patients, the model achieved AUROC values of 0.818 and 0.811 for predicting one and two-year recurrence respectively. Validation with an external…
Transarterial embolization (TAE) demonstrates a 100% hemostasis success rate in treating ruptured hemorrhages and postablation bleeding in liver cancer patients. The 30-day survival rates were 90.91% for the rupture group and 100% for the ablation group, with 1-year survival rates of 45.45% and 85.19%, respectively.…
Higher stages of the OLGA and OLGIM staging systems significantly correlate with an elevated risk of developing high-grade dysplasia (HGD) and gastric cancer (GC). A systematic review and meta-analysis of eight prospective cohort studies found that moving from OLGA/OLGIM categories 0-II to III-IV notably increases…
A retrospective analysis of 121 patients with necrotizing fasciitis revealed that early diagnosis within six hours reduced mortality rates to 5.7% compared to 13.2% for later diagnoses. Patients receiving timely intervention experienced shorter hospital stays, averaging 17 days versus 27 days. Additionally, a combination of…
Recent advancements in colorectal cancer detection emphasize molecular biomarkers and imaging techniques. Innovations, including genetic, epigenetic, and protein biomarkers, improve disease identification. Radiological imaging developments provide crucial insights into tumor biology beyond morphology. Combining these advancements with statistical methods enhances diagnostic sensitivity and specificity. However,…
A retrospective analysis of 1,388 patients undergoing laparoscopic total extraperitoneal repair for groin hernias demonstrated that the retrograde puncture method for trocar placement is both feasible and safe. All surgeries were successful without conversion to open procedures. Notably, the average time for unilateral trocar placement…
Analysis of 23 studies with 167,904 colorectal cancer patients identified key risk factors for postoperative acute kidney injury (AKI). Notably, male sex, older age, and a body mass index (BMI) ≥ 25 kg/m² were linked to increased risk. The systematic review emphasizes the necessity for…
A retrospective analysis of 102 patients undergoing open abdominal wall reconstruction revealed that those receiving quadratus lumborum blocks experienced minimal opioid consumption in the first 24 hours post-surgery, with a median of 8 morphine milliequivalents (MMEs). By day 2, opioid use peaked at a median…
A national study involving 4,530 patients from 23 hospitals revealed that 70.9% of intra-abdominal infections were community-acquired, with appendicitis cases showing an even higher rate of 98.2%. E. coli emerged as the primary pathogen in 45.6% of infections. The study also reported a 5.13% mortality…
