Newsletter
Best Papers in General Surgery
The five that matter, every day.
A study analyzing 530,711 colorectal cancer patients revealed a significant suicide risk, particularly among males aged 35-49 and over 60. Of the 782 suicides recorded, 88% occurred in men, with a standardized mortality ratio of 1.60. Key factors elevating suicide risk included distant disease, radiation…
An AI-assisted coaching program significantly improved novice surgeons' performance in laparoscopic cholecystectomy, raising evaluation scores from 31 to 40 (p=0.008) and surpassing self-learning group scores by the study's end (40 vs. 38, p=0.032). The coaching group also achieved a notable increase in the critical view…
In a retrospective analysis of 381 rectal cancer patients, early-onset rectal cancer (EORC) patients, those younger than 50, showed a higher pathological complete response rate (29%) compared to late-onset patients (18.8%). Despite more aggressive neoadjuvant treatments in the EORC group, the type of treatment did…
In biliary tract cancers (BTCs), genomic analysis revealed distinct variations in mutations across cancer subtypes based on anatomic and geographic factors. Notably, intrahepatic cholangiocarcinoma samples showed prevalent alterations in IDH1 and FGFR2, while gallbladder cancers frequently displayed TP53, ERBB2, and SMAD4 mutations. Co-mutations were ubiquitous,…
An updated meta-analysis involving 11,981 gastric cancer patients revealed that preoperative sarcopenia is linked to substantial postoperative complications, including increased rates of mortality, readmission, and severe complications. Sarcopenic patients exhibited notably higher incidences of pulmonary issues, bowel obstructions, and pancreatic fistulas, leading to significantly poorer…
Addressing climate change, researchers highlight its disproportionate effects on low- and middle-income countries (LMICs), where health outcomes decline due to environmental factors. They emphasize that while expanding surgical care improves access, it risks exacerbating environmental degradation, raising challenges for vulnerable populations already facing health inequity.…
A study involving 4,018 colorectal cancer patients revealed that the hemoglobin to albumin ratio (HAR) serves as a significant prognostic factor. Patients with a high HAR demonstrated better overall survival (OS) and disease-free survival (DFS) compared to those with a low HAR, particularly in stage…
In a phase 3 study involving 616 patients with unresectable hepatocellular carcinoma, the combination of durvalumab and bevacizumab, alongside transarterial chemoembolisation (TACE), significantly improved median progression-free survival to 15 months compared to 8.2 months with placebo. The hazard ratio for progression-free survival was 0.77, indicating…
Among 4,429 patients undergoing gastric adenocarcinoma resection (2016-2022), minimally invasive surgery (MIS) was linked to lower complication rates compared to open gastrectomy, with fewer major complications (13.1% vs. 18.5%) and reduced perioperative mortality (0.57% vs. 1.53%). Despite these benefits, MIS utilization remained stagnant, indicating a…
A nomogram was developed to predict early cancer-related death (ecrd) due to recurrence in hepatocellular carcinoma (HCC) patients with BCLC stage B/C. Analysis of 672 patients revealed that the alpha-fetoprotein-tumor burden score, BCLC stage, and AST to ALT ratio were significantly associated with ecrd. The…
