Newsletter
Best Papers in General Surgery
The five that matter, every day.
French intergroup clinical practice guidelines for managing rectal adenocarcinoma were published in September 2023. The guidelines categorize treatment based on tumor stage, with specific recommendations for endoscopic and surgical excision, radical surgery, and total neoadjuvant treatment. Additionally, they emphasize rectal conservation for select small tumors…
Clinical outcomes from a study of 113 pancreatic cancer patients indicate that preserving the portal/superior mesenteric vein during pancreaticoduodenectomy results in similar oncologic outcomes to resection, with better vessel-functional outcomes. While there was no significant difference in R0 resection rates, overall survival, or recurrence-free survival,…
Among patients with predicted severe acute pancreatitis, the use of balanced multielectrolyte solutions (bmes) led to significantly lower serum chloride levels compared to normal saline (ns) on trial day 3. Additionally, patients receiving bmes experienced reduced systemic inflammatory response syndrome rates, increased organ failure-free days,…
The American Society for Gastrointestinal Endoscopy has published updated guidelines, emphasizing evidence-based diagnosis and management strategies for gastroesophageal reflux disease (GERD). Key recommendations include endoscopic evaluation for patients with alarm symptoms and lifestyle modifications. For those with confirmed GERD, proton pump inhibitors are advised at…
Findings indicate that crystalloid volume supplementation markedly enhances gastric conduit tissue oxygenation (70.5%) compared to permissive hypotension (63.3%), catecholamine therapy (45.9%), and combined therapy (69.0%). The correlation between tissue oxygenation and systemic lactate levels further supports its effectiveness. This suggests crystalloid volume supplementation as a…
A cohort study of 9.8 million surgical patients revealed that combining the modified frailty index 5 (mfi-5) with hypoalbuminemia significantly enhances predictive accuracy for surgical outcomes. The analysis indicated that the combined assessment outperformed individual predictors in identifying risks for 30-day mortality, complications, and hospital…
A comprehensive analysis of 75 studies involving 13,010 patients reveals that goal-directed haemodynamic therapy (GDHT) significantly lowers the incidence of surgical site infections (SSI) from 13.3% in conventional fluid therapy to 9.4%, marking an absolute risk reduction of 3.9%. With high-certainty evidence, GDHT demonstrates a…
A randomized clinical trial revealed that inexperienced clinicians receiving just-in-time coaching achieved a first attempt success rate of 91.4% for infant orotracheal intubation, compared to 81.6% in the control group. This significant difference (odds ratio 2.42, p=0.001) suggests enhanced procedural quality. Additionally, the intervention group…
A predictive and prognostic signature, named chemoresist, effectively identifies pancreatic ductal adenocarcinoma patients likely to benefit from adjuvant chemotherapy. In a multicenter study involving 551 patients, the chemoresist classifier demonstrated significant survival differences between high- and low-score patients, outperforming traditional TNM staging. It achieved higher…
A study evaluated deep learning, radiomics, and fusion models to predict KRAS mutations in rectal cancer using endorectal ultrasound images from 304 patients. Among the models, the feature-based fusion model (dlrexpand10_fb) achieved the highest area under the receiver operating characteristic curve (AUC) of 0.896, indicating…
