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Best Papers in General Surgery
The five that matter, every day.
In a study involving octogenarians with acute cholecystitis, percutaneous cholecystostomy (PC) improved preoperative conditions, including systemic inflammation and blood coagulation abnormalities, compared to upfront surgery (US). Patients undergoing PC had worse initial health status but exhibited higher elective surgery rates post-treatment. Remarkably, despite the complexity…
A study of 11,827 surgical cases revealed that ICD-10 codes identified only 20.8% of postoperative complications (PCs) compared to 1047 PCs identified through manual curation. Patients with PCs faced significantly increased resource utilization, including a 6.6 times higher readmission rate and considerable economic costs, amounting…
Enhanced imaging techniques have led to increased detection of pancreatic cystic lesions. A study of 88 patients revealed that endoscopic ultrasound fine needle aspiration (EUS-FNA) allowed for precise characterization of these lesions, with some demonstrating worrisome features requiring surgical intervention. Most patients had a history…
Patients with recurrent colorectal liver metastases who underwent repeat liver resection experienced significantly better long-term outcomes compared to those who did not, with five-year overall survival rates of 66.3% versus 27.2% respectively. Key prognostic factors include having four or more recurrent tumors, tumors larger than…
The 2024 GI Surgery Summit highlighted essential strategies for recruiting and training future surgeons amid evolving healthcare demands. Prominent leaders emphasized the need for diversity and innovative educational frameworks to enhance surgical training. The discussions underscored the importance of building a robust global surgical workforce…
A study examining anastomotic doughnuts from 102 patients found that minimal width of the oral and aboral doughnuts notably correlated with anastomotic leakage (AL) rates, which were 15.7%. The oral and aboral minimal widths were significantly lower in AL cases compared to non-Leakage cases. In…
A study involving 150 patients undergoing major hepatectomy for hilar cholangiocarcinoma identified critical risk factors for postoperative liver failure. The combined assessment of future remnant liver volume to total liver volume ratio (frlv/tlv) and indocyanine green clearance fraction (icgk-f) proved effective in predicting complications. Patients…
Tumor-derived organoids have emerged as crucial tools in diagnosing and modeling primary liver cancers, particularly hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Among 39 studies analyzed, most organoids were patient-derived, showcasing their role in biomarker discovery and therapeutic exploration. Innovative approaches like organoid-on-a-chip systems suggest promising advancements…
Analysis of 24 studies revealed that mutations in kras, idh1/2, and tp53 significantly affect long-term survival outcomes in patients with resectable intrahepatic cholangiocarcinoma. Specifically, kras mutations increased the risk (HR: 2.476), while idh1/2 mutations suggested a protective effect (HR: 0.624). tp53 mutations also indicated a…
Analysis of immune markers in healthy rectal mucosa indicates that certain cellular profiles, such as high CD8β infiltration, are significant predictors of tumor spread and recurrence in patients after transanal excision for rectal cancer. The study found strong correlations between low activation of CD8+ T…
