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Best Papers in General Surgery
The five that matter, every day.
After bariatric surgery, many patients experience insufficient weight loss or regain. This study examines the utilization of anti-obesity medications (AOMs) post-surgery using a large database. Among 59,160 patients, AOM use was highest for topiramate, with varying age and racial distributions. Despite weight concerns, AOMs are…
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a leading cause of liver transplantations in western countries, with metabolic dysfunction-associated steatohepatitis (MASH) progressing to fibrosis, cirrhosis, and liver failure. Researchers anticipate the approval of the first drug for MASH by 2024, exploring pathways like thyroid…
Long-term surveillance of IPMNs led to early diagnosis and better outcomes of concomitant PDAC. Patients with IPMNs had higher rates of early cancer stage identification and R0 resection compared to those without IPMNs. Concomitant PDACs were associated with longer overall survival, with a 5-year survival…
Researchers analyzed 727 pancreatic cancer patients who received neoadjuvant therapy and pancreatectomy from 1998 to 2018. They found an increase in neoadjuvant chemotherapy use and a shift in the timing of recurrence risk from postoperative year 1 to year 2. Overall survival improved over time,…
Moabp significantly reduced overall postoperative complications, surgical site infections (SSIs), and anastomotic dehiscences in patients undergoing elective rectal resection compared to those receiving mechanical bowel preparation (MBP) plus a placebo. Patients in the Moabp group had lower rates of complications and SSIs, highlighting the potential…
Research examined payer-negotiated prices for surgical oncology services at NCI-designated cancer centers and their impact on clinical outcomes. Prices varied greatly within and between centers, but the effect on morbidity and mortality was statistically significant, yet clinically negligible across colon, lung, and pancreas cancer cohorts.…
Researchers explore the concept of biologic resectability in defining patient selection for metastasectomy in oligometastatic pancreatic ductal adenocarcinoma (PDAC). They assess safety and oncologic outcomes of metastasectomy in liver, peritoneum, and lung, and evaluate biomarkers like radiographic findings, biochemical markers (CA 19-9, CEA), and inflammatory…
Combining the Glissonean approach and indocyanine green fluorescence imaging aids in performing laparoscopic right anterior sectionectomy with precision, particularly in locating transection planes near the middle and right hepatic veins. In a case study, this technique enabled successful resection of a hepatocellular carcinoma with minimal…
Systematic review and meta-analysis of hepatic artery-based therapies and systemic chemotherapy for unresectable colorectal liver metastases showed high overall survival rates for hepatic artery infusion and favorable outcomes compared to doublet chemotherapy in specific subgroups. Triplet chemotherapy had the best outcomes but with higher toxicity…
Older patients undergoing elective ventral hernia repair were categorized based on frailty, with severely frail patients showing lower quality of life at baseline. Surprisingly, severely frail patients reported higher quality of life scores at 30 days and 6 months postoperatively compared to non-frail patients. Despite…
