Researchers developed prediction models using preoperative data to assess short-term mortality risk following colorectal cancer surgery. The models showed good discrimination and calibration, with an area under the receiver operating characteristic curve of 0.88, 0.878, and 0.861 for 30-day, 90-day, and 1-year mortality, respectively. Subgroup analysis did not improve discrimination or calibration. Combining all operated […]
Category: General Surgery
Machine learning does not outperform expert-informed predictions for outcome after major liver surgery
Expert-informed prediction models and machine learning models both showed similar performance in predicting postoperative overall morbidity in liver surgery patients, with high variability and over/underprediction. There was no improvement in performance for major liver surgery patients, indicating that machine learning may not have clinical relevance for predicting postoperative outcomes at this stage. Journal Article by […]
Impact of Pancreatic Duct Topography on Surgical Outcomes in Pancreatic Cancer
Findings from a study on 105 patients who underwent Whipple’s procedure for pancreatic cancer revealed that inferior pancreatic duct topography was linked to higher rates of metastatic spread and tumor recurrence, as well as reduced overall and recurrence-free survival. Conversely, posterior pancreatic duct topography was associated with lower incidence of perineural sheet infiltration and improved […]
Isolated Hepatic Perfusion with Melphalan in Uveal Melanoma Liver Metastases: Survival and Health-related Quality of Life Results
Survival and quality of life outcomes in patients with uveal melanoma liver metastases treated with isolated hepatic perfusion were evaluated in a Phase III randomized controlled trial. Isolated hepatic perfusion led to significantly longer progression-free survival compared to standard care, but no significant difference in overall survival at 24 months. Patients receiving isolated hepatic perfusion […]
Active Surveillance for Complete Responders in Oesophageal SCC: Better Progression-Free Survival
Patients with oesophageal squamous cell carcinoma who underwent active surveillance after chemoradiotherapy showed comparable overall survival but better progression-free survival than those who had planned surgery. The two groups had similar overall recurrence rates, with locoregional recurrence more common in the active surveillance group and systemic recurrence more common in the surgery group. Active surveillance […]
Impact of Behavioral Health Disorders on Surgical Outcomes and Survival of Cancer Patients
Patients with behavioral health disorders (BHD) had lower rates of resection and higher odds of complications, longer hospital stays, readmission, and higher in-hospital expenditures. They were also less likely to achieve a postoperative textbook outcome and had worse long-term survival. Initiatives targeting BHD are crucial to improve surgical outcomes and prognosis in cancer patients. Journal […]
Does Laparoscopic Gastric Ischemic Preconditioning Reduce Anastomotic Stricture Rate After Esophagectomy?
According to the study, laparoscopic gastric ischemic preconditioning (LGIP) may decrease the rate and severity of anastomotic strictures following esophagectomy. Of the patients who underwent LGIP, only 7.1% developed anastomotic strictures compared to 19.9% in the control group. While controlling for confounders, the difference was no longer significant. There was also a trend towards less […]
Low Colorectal Cancer Risk After Resection of High-Risk Pedunculated Polyps
CRC incidence is significantly higher in patients with high-risk adenomas (HRAs) diagnosed at colonoscopy, with a 1.53-fold increase in risk. However, patients with only distal pedunculated polyps without high-grade dysplasia do not have an increased CRC risk. The presence of certain risk factors explains most of the excess CRC risk in the HRA group, indicating […]
Improvement in Clinical Outcomes and Diagnostic Accuracy with Multidisciplinary Management of Retroperitoneal Liposarcoma
Multidisciplinary team management in retroperitoneal liposarcoma treatment led to higher overall survival rates at 1, 3, and 5 years, improved diagnostic consistency, reduced perioperative mortality and postoperative complications, and enhanced disease awareness and postoperative compliance. The intervention showed significant benefits in clinical outcomes and diagnostic accuracy, highlighting the importance of multidisciplinary approaches in managing retroperitoneal […]
What are the distinct quality-of-life trajectories after pelvic exenteration?
Quality of life trajectories after pelvic exenteration diverge into distinct classes, with most patients experiencing optimal outcomes. Two classes were identified for physical scores and three for mental and functional scores, with higher overall survival probabilities in the optimal trajectory class. Age, repeat surgery, neoadjuvant therapy, surgical margin, operation duration, and hospital stay were significant […]