Pancreatic ductal adenocarcinoma patients exhibit varied responses to therapy, with molecular subtyping revealing classical and basal-like subtypes, the latter associated with poorer outcomes. Two main tumor subtypes were identified, along with high-risk stromal subtypes linked to worse survival. Superior survival was seen with classical subtype. Despite challenges in cost and data volume, molecular subtyping can […]
Category: General Surgery
Impact of Unplanned Conversion on Patient Survival after Laparoscopic Liver Resection for Hepatocellular Carcinoma
Unplanned conversion during laparoscopic liver resection for hepatocellular carcinoma is associated with higher blood loss, transfusion rate, hospital stay, and postoperative complications. However, the 5-year overall survival rate was similar in patients who underwent unplanned conversion and those who underwent laparoscopic liver resection. Journal Article by Lee B, Cho JY (…) Kim J et 5 […]
Disparities in Access and Outcomes for Latino Californians with Colon Cancer
Latino colon cancer patients in California face disparities, with lower rates of surgical resection, delays, and reduced receipt of recommended care compared to non-Latino White counterparts. Access to high-volume hospitals is linked to improved outcomes for Latino patients, emphasizing the importance of directing at-risk individuals to such facilities for enhanced health equity. Journal Article by […]
Virtual Formats Threaten Surgical Informed Consent’s Moral Ends
Virtual informed consent, adopted during the COVID-19 pandemic, persists despite its resolution, challenging the traditional “information-transfer” model. This study argues for a “trust-building” model, emphasizing the interpersonal and systemic aspects of consent. It explores the limitations of virtual formats in fulfilling this comprehensive understanding and proposes an ethical framework for physicians navigating this novel virtual […]
Sizing Protocol Does Not Impact Outcomes of Magnetic Sphincter Augmentation
Sizing protocol (pop+2 vs pop+3) in magnetic sphincter augmentation did not impact outcomes like dysphagia, ph normalization, or need for dilation or removal. Upsizing did benefit patients with poor peristalsis or hypercontractile esophagus. Device size increase correlated with demographic and preoperative characteristics, suggesting it is a surrogate for esophageal circumference. Journal Article by Sarici IS, […]
Key Advances in Multimodality Management of Gastroesophageal Cancers
Recent studies have confirmed the long-term safety and efficacy of laparoscopic distal gastrectomy compared to open gastrectomy for locally advanced gastric cancer. Ongoing trials are evaluating perioperative immunotherapy for resectable gastric cancers. Key trials like dante, gercor neonipiga, keynote-859, and spotlight are exploring targeted therapies for unresectable or metastatic gastroesophageal cancers, incorporating immune checkpoint inhibitors […]
Development of a nomogram predicting postsurgical intra-abdominal infection in blunt abdominal trauma patients
A clinical model was developed to predict postsurgical intra-abdominal infection in blunt abdominal trauma patients based on a retrospective analysis of 553 patients from 7 medical centers. Independent risk factors were identified, including age, prehospital time, c-reactive protein, injury severity score, operation duration, intestinal injury, neutrophils, and antibiotic use. The nomogram showed good predictive performance […]
Primary Sclerosing Cholangitis and Extraintestinal Manifestations in Ileal Pouch Patients
Restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis improves quality of life but may not fully resolve extraintestinal disorders like primary sclerosing cholangitis, joint, skin, and eye issues. Treatment of pouchitis does not impact primary sclerosing cholangitis, but biologic therapies for pouch inflammatory disorders may benefit joint, skin, and eye manifestations. Journal Article by […]
Sleeve Gastrectomy: A Vital Reducer of Liver Transplantation Need in Non-Alcoholic Steatohepatitis Patients
Simulation of 20,000 obese patients with non-alcoholic steatohepatitis found that sleeve gastrectomy (SG) led to a gain of 14.3 years compared to medical weight management (MWM), with only 5% of SG patients requiring liver transplantation (LT) after one year, compared to 9% in the MWM group. SG reduced the need for LT in patients with […]
Operative Trends Unchanged Despite Nonoperative Management Adoption in Rectal Cancer
A single institution retrospective analysis of rectal cancer cases before and after the adoption of a nonoperative “watch and wait” pathway found no significant increase in abdominoperineal resection for patients without a complete clinical response to neoadjuvant therapy. Although there was a higher rate of pathologic complete responses in the post-“watch and wait” period, restaging […]