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Best Papers in General Surgery
The five that matter, every day.
A comparative study evaluated the short-term and long-term outcomes of the "superior mesenteric artery first" (SMA-first) approach versus the conventional approach in pancreatic ductal adenocarcinoma (PDAC) patients undergoing laparoscopic pancreaticoduodenectomy. The SMA-first approach demonstrated a higher number of harvested lymph nodes and a lower involvement…
A retrospective study of 207 colorectal cancer patients found that muscle quality, rather than quantity, significantly impacts surgical outcomes. The study demonstrated that patients with higher muscle radiation attenuation (MRA), a measure of muscle quality, experienced fewer postoperative complications, shorter hospital stays, and improved survival…
The study aimed to evaluate the role of immunocyte-derived ratios (IDRs) as potential markers for postoperative recovery of gastrointestinal function after colorectal cancer surgery. The retrospective analysis of 260 patients revealed a positive correlation between IDRs (systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio) and the…
The study reviewed medical literature to assess the use and clinical significance of Fredet's fascia in complete mesocolic excision (CME) for right-sided colon adenocarcinoma. The results showed limited utilization of the term "Fredet's fascia" in English medical literature and conflicting definitions and boundaries. The researchers…
Adipose tissue-derived mesenchymal stem cells (ADMSCs) were investigated for their potential in reducing inflammation and preventing anastomotic leak in rats with inflammatory bowel disease. Rats were divided into four groups, and those with induced intestinal inflammation were treated with ADMSCs prior to surgery. The study…
An international consensus has been reached on the definition of textbook oncologic outcomes (TOO) in cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal peritoneal metastasis. The TOO parameters for CRS/HIPEC in this context include absence of certain complications, achievement of complete cytoreduction, and…
Robotic resection for perihilar cholangiocarcinoma is a safe and feasible approach with acceptable short-term clinical and oncological outcomes. In a multicenter study of 38 patients, the majority had Klatskin type-3 tumors. The median age was 72 years, and most patients underwent preoperative biliary drainage. The…
This study evaluated the combined use of three tumor markers (CEA, CA72-4, and CA19-9) for prognostic assessment in gastric cancer patients. Data from 1,966 patients who underwent curative gastrectomy were analyzed, and hazard ratios were calculated. The results showed that the combined use of tumor…
Among patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for nongynecologic cancers, intra- and interpatient drug response heterogeneity was observed. Researchers generated patient-derived tumor organoids (PDTOs) and conducted in vitro drug screens to assess drug response. PDTOs were successfully generated from 13 out of…
Perioperative chemotherapy is associated with superior overall survival in patients with synchronous colorectal liver metastases. Resection of both the primary and metastatic sites is linked to better overall survival. The study also found that patients who received perioperative chemotherapy had significantly longer overall survival compared…
