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Best Papers in General Surgery
The five that matter, every day.
Incidentally detected T2 gallbladder cancer (pt2 GBC) has been found to have significantly worse outcomes compared to similarly staged patients who undergo upfront radical cholecystectomy. A retrospective analysis of 425 cases revealed that patients with incidentally detected tumors had higher rates of locoregional, liver, and…
Patients with re-resected incidental gallbladder carcinoma (rrigbc) had better prognosis and were at earlier tumor stage compared to those with primary radically resected gallbladder carcinoma (prgbc). Subgroup analysis revealed similar outcomes for patients with T1-2 tumors in both groups. However, patients with T3-4 tumors in…
Calcium channel blockers (CCB) were found to be associated with improved overall survival in pancreatic cancer patients undergoing neoadjuvant chemotherapy and resection. A retrospective study of 6,223 patients showed that CCB prescription was specifically beneficial in the subgroup receiving neoadjuvant chemotherapy, reflecting the chemosensitizing effect…
In a study analyzing pancreatic cancer patients aged 80 years and above, it was found that non-home discharge after pancreatoduodenectomy (PD) was more than twice as likely to occur in this age group compared to those aged 65-79 years. Comorbidity factors such as COPD, hypertension,…
A retrospective analysis of 370 patients who underwent pancreatic resection surgery in Austria revealed that the incidence of postoperative diabetes mellitus (postopdm) was 29%. Postopdm occurred significantly more frequently in patients with malignant pancreatic diseases compared to benign diseases (31.3% vs. 16.7%). The study highlights…
Hospital performance for general surgery varies between younger and older adults, with in-hospital mortality rates showing significant differences. Failure-to-rescue rates drive the variation in older adults, while both complication and failure-to-rescue rates contribute to high mortality rates in younger adults. Correlations between observed-to-expected mortality ratios…
Indirect signs of portal hypertension (pht) don't raise complications risk in hepatocellular carcinoma (HCC) patients undergoing liver resection (LR). However, in patients with hepatic venous pressure gradient (HVPG) ≥10 mmHg, LR significantly increases overall morbidity and liver-related complications risk. Transjugular HVPG assessment is crucial for…
The study evaluates the validity of using pathological response as a surrogate marker for overall survival (OS) in neoadjuvant studies for esophageal cancer. A meta-analysis comprising 40 trials and 55,344 patients shows that the surrogacy between pathological complete response (PCR) and OS is moderate. The…
Researchers developed an MRI-based prediction model for anti-TNF treatment failure in perianal Crohn's disease. The model, based on clinical and radiologic parameters, accurately predicts the likelihood of treatment failure and outperforms existing imaging-based indices. The study included 221 patients, with treatment failure occurring in 46%…
A prospective cohort study conducted at a tertiary colorectal center aimed to identify predictive factors for successful same-day discharge following minimally invasive colorectal surgery. Out of 175 patients, 161 (78.5%) were discharged on the day of surgery without complications, while 44 (21.5%) experienced same-day discharge…
