Skin wound healing often leads to abnormal scarring, such as keloids or hypertrophic scars, impacting millions globally. While the precise mechanisms remain elusive, evidence suggests ongoing inflammation in susceptible individuals perpetuates extracellular matrix changes, resulting in fibrotic lesions. Abnormal scarring, causing pain, functional impairment, and aesthetic concerns, lacks effective treatment. The study underscores the urgent […]
Category: General Surgery
Limited Exploration of Feasibility in Surgical Placebo Trials
Examining 131 randomized placebo-controlled surgical trials, a systematic review revealed a scarcity of published pilot or feasibility studies to inform the design and execution of these challenging trials. Only four studies, focused on orthopedic and oral/maxillofacial surgery, conducted true pilot work. With a dearth of reported feasibility efforts, the study underscores the necessity for more […]
Best Practices in Regression Analysis for Surgical Oncology Research: A Practical Guide
Analyzing tissue expander breast reconstruction cases (n=1986), researchers offered practical insights into regression modeling in surgical oncology. For breast-Q physical well-being, linear regression identified age, marital status, and dissection type as significant factors. Logistic regression for complications found BMI, age, bilateral reconstruction, and dissection type impactful. The study provides focused directives, urging researchers to judiciously […]
Surgeon-Patient Sex Discordance Hinders Optimal Outcomes in Complex Cancer Surgery
Analyzing 495,628 patients undergoing complex cancer surgery, researchers found that sex discordance between surgeons and patients (51.2%) was linked to a decreased likelihood of achieving optimal postoperative outcomes. Such discordance correlated with higher risks of complications and 90-day mortality. Intriguingly, male patients treated by female surgeons exhibited outcomes comparable to female patients treated by male […]
Tailoring Prophylaxis in Crohn’s Disease Surgery: Real-world Insights into Risk Factors and Recurrence
Examining 1404 Crohn’s disease patients post-ileocecal resection, researchers identified high-risk factors for surgical recurrence (multiple surgeries, active smoking, penetrating or perianal disease). Biologic prophylaxis post-surgery lowered surgical recurrence in high-risk patients. Additionally, prophylaxis reduced endoscopic recurrence regardless of risk, suggesting its potential benefits across risk profiles. These findings emphasize the relevance of individualized prophylactic approaches […]
ECCO Workshop Yields Postoperative Management Algorithm for Crohn’s Disease Patients
The 8th ECCO scientific workshop addressed postoperative recurrence (POR) in Crohn’s disease after ileocolonic resection. Despite modern therapies, POR remains a challenge, impacting patients’ lives. The workshop extensively reviewed data on preventive and treatment strategies, including medications, endoscopic procedures, and surgery. Synthesizing available knowledge, the workshop produced a practical algorithm for managing POR in daily […]
Prophylactic Dexamethasone in Hepatectomy with 25-Min Intermittent Pringle’s Maneuver for Hepatocellular Carcinoma: A Randomized Trial
In hepatectomy for hepatocellular carcinoma (HCC) using a 25-minute Intermittent Pringle’s Maneuver (IPM), preoperative dexamethasone administration demonstrated benefits. The study included 270 patients, with the dexamethasone group exhibiting reduced hepatocellular injury, inflammatory response, and major complications, along with shorter hospital stays compared to the control group. Notably, subgroup analyses indicated milder hepatocellular injury for cirrhotic […]
Mutation-Annotated Prognostic Score for Intrahepatic Cholangiocarcinoma: Development and Validation
Researchers developed a Mutation-Annotated Prognostic Score (MAPS) for intrahepatic cholangiocarcinoma (ICC) after resection, integrating TP53 and KRASG12 mutations with clinical parameters. The MAPS model, validated internally and externally, demonstrated superior predictive efficacy (c-indices 0.782 and 0.731, respectively) compared to existing models. It effectively identified ICC patients’ overall survival and showed promise in predicting benefits from […]
Minimally Invasive Distal Pancreatectomy Outcomes for Left-Sided Tumors: Impact of Modified Frailty Index
Examining 2,212 patients undergoing minimally invasive distal pancreatectomy (MIDP) for left-sided tumors, this study categorized participants into frail and nonfrail groups using the modified frailty index (MFI). The frail group (n=79) exhibited significantly higher clinically relevant postoperative pancreatic fistula, overall complications, and 90-day mortality (1.3%). MFI ≥0.27, extended pancreatectomy, BMI ≥30 kg/m², male sex, and […]
Short-Term Outcomes of Laparoscopic Anatomical Liver Resection of Segment 8 for Hepatocellular Carcinoma
Examining 122 patients across seven Chinese centers, researchers evaluated three laparoscopic approaches for anatomical liver resection of segment 8 (LALR-S8) in hepatocellular carcinoma. The laparoscopic ultrasonography-guided, hepatic vein-guided, and Glissonean approaches showed comparable short-term oncological outcomes. Complication rates were low (5.73%), with the hepatic vein-guided approach being the most utilized. The study affirms the safety […]