Newsletter
Best Papers in General Surgery
The five that matter, every day.
Investigating primary hyperparathyroidism referrals, a study analyzed 1,100 patients and found that sex concordance (matching patient and practitioner sexes) correlated with increased specialist evaluations. Patients with concordant primary care practitioners had 32% higher odds of endocrinologist evaluation, and those with concordant endocrinologists had a 48%…
In the era of widespread colonoscopy, many patients later diagnosed with esophageal adenocarcinoma (EA) had prior screening colonoscopies, presenting missed opportunities for earlier detection. Among 221 referred patients, 49% had prior colonoscopies, yet only 18% had an esophagogastroduodenoscopy (EGD) before EA diagnosis. Most displayed gastroesophageal…
Comparing neoadjuvant radiochemotherapy protocols for resectable esophageal cancer, this study finds no significant differences in postoperative mortality, complications, or toxicity. Both PF-based and CROSS protocols demonstrate effectiveness and safety, with squamous cell carcinoma and favorable tumor grading independently predicting a higher pathological complete response rate.…
Surviving biliary sepsis: A retrospective study in a cancer center unveils a 30.3% 90-day mortality rate, with factors like metastatic stage, biliary tract tumor compression, and multi-drug resistant bacteria influencing outcomes. Antibiotic de-escalation emerges as a safe strategy, linked with better survival. Beyond organ dysfunctions,…
Hepatitis D Virus (HDV) hitchhikes on Hepatitis B Virus (HBV), impacting 12 to 72 million globally with accelerated liver disease progression. Chronic HDV-HBV infection, deadlier than HBV alone, leads to cirrhosis and hepatocellular carcinoma. Limited awareness hampers diagnosis, but the HBV vaccine offers prevention. Interferon…
Embracing modern surgical trends, this study scrutinizes the safety of brief hospital stays (≤24 hours) after left colectomy for colon cancer. Among 15,745 patients, a mere 1.87% experienced short stays, proving younger, healthier, and with lower morbidity rates than extended stays. Notably, short-stay patients exhibited…
In the realm of thyroid cancer, where iodine treatment falls short for some, researchers explored a new ally. The thyroid-stimulating hormone receptor (TSHR) took the spotlight, showing up in 62% of patients' thyroid tissues. With a specially crafted radiolabeled compound, researchers witnessed TSHR's potential for…
In the quest for effective gastroenteropancreatic neuroendocrine carcinoma treatments, researchers unleashed patient-derived tumor spheroids. A dazzling 16 compounds, notably tyrosyl-DNA phosphodiesterase 1 inhibitors, emerged as fierce warriors against over 75% of these rare tumors. Cytarabine, a standout from the bunch, synergized with standard drugs, intensifying…
In exploring single-incision laparoscopic gastrectomy for early gastric cancer, researchers found it safe and feasible compared to multiport laparoscopy. Analyzing cases from 2013 to 2021, the single-incision approach showed similar operation times and length of stay. Complication rates were comparable, supporting the cautious adoption of…
For severe infected necrotizing pancreatitis, researchers compared endoscopic and minimally invasive surgical (MIS) treatments in a meta-analysis. Analyzing five randomized controlled trials with 284 patients, endoscopic procedures (145 patients) outperformed MIS (139 patients), demonstrating significantly lower complication rates and better patient quality of life.
