Researchers found that endoscopic submucosal dissection (ESD) offers superior clinical outcomes for early oesophageal cancer compared to endoscopic mucosal resection (EMR). ESD demonstrated a shorter hospitalization time (7.51 vs. 9.16 days) and a significantly better postoperative quality of life. Although ESD surgeries took longer, both techniques achieved comparable resection rates. Importantly, ESD resulted in fewer […]
Category: Surgical Endoscopy
Emerging endoscopic techniques improve diagnosis and treatment of pancreatic cysts
Accurate diagnosis of pancreatic cystic lesions (PCLs) is critical to avoiding unnecessary surgeries. Despite existing guidelines, many patients with benign cysts still undergo major resections. New endoscopic methods, including advanced imaging and minimally invasive treatments, show promise for enhancing diagnostic precision and offering organ-sparing options. Techniques like endoscopic ultrasound (EUS) and novel therapeutics are well-tolerated […]
New machine learning model predicts cholangitis risk after ERCP
A novel interpretable machine learning model has been developed to predict post-ERCP cholangitis (PEC) in patients with malignant biliary obstruction (MBO). The model, utilizing data from 2831 patients, identified key risk factors including radiofrequency ablation and white blood cell count. Among various machine learning methods, the XGBoost model outperformed others, predicting PEC risk with accuracy […]
New tool predicts perforation risks during endoscopic submucosal dissection
A novel predictive model for perforation risk during endoscopic submucosal dissection (ESD) has been developed and validated by researchers. In a study involving 1,051 patients, significant predictors included the first 100 procedures, lesion size over 35 mm, and extended operative time. The model demonstrated satisfactory validation performance with an area under the curve of 0.7078 […]
Cryopreserved fibroblast sheets reduce esophageal leakage risk
Cryopreserved allogeneic multilayered fibroblast sheets demonstrated efficacy in preventing esophageal anastomotic leakage in a rat model. The incidence of leakage was significantly lower in the fibroblast sheets group (28%) compared to controls (61%; p = .02). Additionally, the burst pressure was notably higher in the sheet group (124 ± 30 mm Hg) versus controls (78 […]
GNAS droplet digital PCR enhances mucinous cyst diagnosis
A single GNAS droplet digital PCR (ddPCR) analysis improves the diagnostic accuracy for mucinous pancreatic cystic lesions (MPCNs) using endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Among 140 patients, ddPCR increased MPCN detection to 62% while yielding 100% specificity. The method also identified a third of inconclusive lesions as MPCNs. Importantly, GNAS-ddPCR demonstrated a 24% cost reduction […]
Hydrogels may reduce esophageal stricture risk post-ESD.
Innovative hydrogel interventions show promise in significantly reducing stricture rates following endoscopic submucosal dissection for early esophageal cancer. Current methods have limited effectiveness and safety concerns, but hydrogels offer biocompatibility and enhanced therapeutic delivery. They promote epithelial regeneration and reduce fibrosis, potentially improving long-term outcomes. This review highlights the transformative potential of hydrogels in clinical […]
Etomidate-opioids show promising sedation balance for endoscopy
A systematic review and network meta-analysis of 152 trials involving 26,527 patients reveals no pharmacological regimen superior to propofol-opioids for sedation success in gastrointestinal endoscopy. However, etomidate-opioids ranked highest for sedation success, bradycardia, and recovery time, significantly reducing hypoxia risk compared to propofol-opioids. Esketamine-remimazolam exhibited superior hemodynamic stability and faster alertness but lower sedation success. […]
Improving adherence to antithrombotic management in endoscopy
A review highlights that inconsistent adherence to guidelines for peri-endoscopic management of antithrombotic agents poses significant challenges. Identified barriers include insufficient education, delayed updates, and unclear responsibilities. Strategies proposed for improvement encompass enhanced education for healthcare providers and patients, digital clinical decision tools, unified management teams, and international collaboration. These initiatives aim to reduce discrepancies […]
Endoscopic intermuscular dissection shows promise for rectal cancer
A study on endoscopic intermuscular dissection (EID) for deep submucosal invasive rectal cancer (d-smic) reports encouraging three-year outcomes. The procedure achieved a 94.1% en bloc resection and 82.5% R0 resection rates. In low-risk patients under active surveillance, locoregional recurrence rates were low (7%), while intermediate-risk had a 13% rate, all salvageable. Notably, there were no […]