Identification of High-Risk Features for Residual Carcinoma in Esophageal Adenocarcinoma Patients

Esophageal cancer patients treated with neoadjuvant chemoradiation followed by esophagectomy were examined to identify high-risk predictors of residual carcinoma. The study found that the presence of stricture, positive biopsy, signet ring cell histology, and a maximum standardized uptake value (SUV max) >5.4 in the absence of esophagitis were associated with residual cancer. External validation confirmed these high-risk factors, indicating that esophagectomy should not be delayed in patients with these features.