Robotic surgical resection for Siewert II/III adenocarcinoma at the gastro-esophageal junction shows comparable overall survival to both laparoscopic and open techniques. Overall survival rates at 3 and 5 years are similar among robotic (OS OR 1.17; CI 0.10–14.06 and OS OR 0.66; CI 0.39–1.12), laparoscopic, and open approaches. A nonsignificant trend suggests improved disease-free survival […]

Recurrence after curative gastrectomy significantly reduces survival, especially in patients with high lymph node ratios (LNR). The probability of being alive and recurrence-free drops from 66.5% at 12 months to just 33.6% by 58 months. In high-LNR patients, 100% experience recurrence by 36 months, and only 11.3% are alive after recurrence at 12 months. Low-LNR […]

Severity of esophageal anastomotic leak significantly affects long-term survival and complications in patients post-esophagectomy. Out of 2905 patients, 425 (14.6%) developed an anastomotic leak, leading to nearly double the rate of pulmonary complications (46.8% vs. 26.7%; p<0.001). Type III leaks (requiring surgical reintervention) were linked to increased 30-day and 90-day mortality (7.3% vs. 2.7% and […]

A randomized trial shows that a 12-week multidisciplinary rehabilitation program significantly enhances cardiorespiratory fitness in survivors of upper gastrointestinal cancer surgery compared to standard care. Patients in the rehabilitation group saw a mean increase in VO₂peak of 1.5 ml/min/kg at post-intervention and 1.23 ml/min/kg at follow-up. No significant differences were observed in other secondary outcomes […]

Postoperative duodenal stump leakage occurs in 2.6% of gastric cancer patients and is associated with a 90-day mortality rate of 17.2%, emphasizing the need for preventive strategies. 90-day mortality after duodenal stump leakage was significant, with 11 out of 64 patients dying (17.2%). Prognostic factors for increased risk of leakage included preoperative weight loss, unreinforced […]

Definitive chemoradiotherapy (DCRT) yields poor overall and progression-free survival for patients with adenocarcinoma of the esophagus or esophago-gastric junction, underscoring the need for careful patient selection and treatment strategy refinement. Median overall survival (OS) was 19.6 months, with a 3-year OS of only 28%. The 90-day mortality rate was notable at 7.1%. Factors such as […]

High pre-treatment serum interleukin-10 levels are associated with significantly worse overall survival in patients with esophageal squamous cell carcinoma treated with chemoradiotherapy. 1-year overall survival rates were 85% in low IL-10 patients versus 56% in high IL-10 patients; 3-year rates were 50% versus 33%. Both advanced cancer stage and high IL-10 levels independently predicted shorter […]

After neoadjuvant chemoradiotherapy for esophageal cancer, regrowth predominantly affects the mucosal and submucosal layers, suggesting implications for surgical vigilance. In a study of 75 patients with surgical specimens analyzed post-neoadjuvant chemoradiotherapy, 91% had cancer cells in the mucosal layer, and 88% in the submucosa. A significant number of patients showed invasive involvement beyond the mucosa, […]

Achieving textbook outcomes (TO) and textbook oncological outcomes (TOO) is linked to significantly better overall survival and disease-free survival after gastric and esophageal cancer surgeries. For gastrectomy, patients who achieved TO/TOO had a 40% reduction in overall survival risk (HR 0.60) and a 46% reduction in disease-free survival risk (HR 0.54). For esophagectomy, the overall […]