Pancreatectomy Induces Cancer-Promoting Neutrophil Extracellular Traps: Implications for Perioperative Management

Post-pancreatectomy, patients exhibit elevated cancer-promoting neutrophil extracellular traps (NETs), peaking on days 3 and 4, linked to changes in neutrophil biology. NET-inducing cytokines (IL-8, IL-6, G-CSF) increase postoperatively, with the robotic approach potentially reducing NETs compared to open surgery. Patients with pancreatic leaks show increased NET markers. The study suggests pancreatectomy induces cancer-promoting NET formation, with implications for minimizing NETs during the perioperative period.