Post-pancreatectomy, patients exhibit elevated cancer-promoting neutrophil extracellular traps (NETs), peaking on days 3 and 4, linked to changes in neutrophil biology. NET-inducing cytokines (IL-8, IL-6, G-CSF) increase postoperatively, with the robotic approach potentially reducing NETs compared to open surgery. Patients with pancreatic leaks show increased NET markers. The study suggests pancreatectomy induces cancer-promoting NET formation, with implications for minimizing NETs during the perioperative period.
Journal Article by Ivey AD, Pratt HG (…) Boone BA et 7 al. in Ann Surg Oncol
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