Esophagectomy improves 5-year overall survival in locally advanced esophageal adenocarcinoma

Esophagectomy is associated with improved 5-year overall survival in locally advanced esophageal adenocarcinoma. Factors like age, race, treatment location, insurance, and tumor size influence esophagectomy use. Non-surgical treatment, government insurance, low income, non-academic centers, comorbidities, and larger tumors increase the risk of all-cause mortality. Esophagectomy and systemic therapy decrease mortality risk. Patients undergoing esophagectomy had significantly higher 5-year overall survival rates and longer median overall survival compared to those treated non-surgically.