Current short-term evidence suggests that oral antibiotics alone can successfully treat uncomplicated acute appendicitis. A study comparing oral antibiotic monotherapy with combined IV and oral antibiotics over a longer-term follow-up found no significant difference in treatment success rate at year 3. While a slightly higher appendectomy rate was observed with oral antibiotic monotherapy, noninferiority could not be demonstrated. Future studies are warranted to explore oral antibiotic monotherapy as a viable treatment option.
Journal Article by Selänne L, Haijanen J (…) Salminen P et 15 al. in JAMA Surg