A study of 891 Chinese patients revealed distinct risk factors for lymph node metastasis (LNM) and prognosis in submucosal early gastric cardiac (SEGCC) versus noncardiac (SEGNCC) carcinomas. Elderly patients and specific tumor characteristics were more prevalent in SEGCC, which correlated with poorer prognoses. Univariate and multivariate analyses identified female sex and lymphovascular invasion as key independent risk factors for LNM in SEGCC, while SEGNCC showed different defining characteristics. The findings suggest the need for tailored clinical management strategies.
• Why it matters: Predicting lymph node spread in early gastric cancer remains challenging.
Journal Article by Cheng Y, Du M (…) Huang Q et 5 al. in Am J Surg Pathol
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