Extended Antibiotics Mitigate Postoperative Pancreatic Fistula in High-Risk Patients

In patients with an elevated risk of postoperative pancreatic fistula after pancreatoduodenectomy, a 10-day course of extended antibiotics significantly reduced the occurrence of clinically relevant fistulas, as well as associated complications like infections and drain placements. Patients on extended antibiotics had a shorter hospital stay compared to those on standard perioperative antibiotics. These findings support the potential benefits of extended antibiotic therapy in mitigating complications and provide a foundation for further investigation.