Examining 131 randomized placebo-controlled surgical trials, a systematic review revealed a scarcity of published pilot or feasibility studies to inform the design and execution of these challenging trials. Only four studies, focused on orthopedic and oral/maxillofacial surgery, conducted true pilot work. With a dearth of reported feasibility efforts, the study underscores the necessity for more pilot studies to share crucial insights, aiding in the optimization of design for main randomized placebo-controlled surgical trials.
Journal Article by Cousins S, Gormley A (…) Blazeby JM et 4 al. in BMJ Open
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