High Incidence of Pancreatic Exocrine Insufficiency After Non-Pancreatic Upper Gastrointestinal Surgery: Implications for Enzyme Replacement Therapy

Approximately 36% of patients who undergo non-pancreatic upper gastrointestinal surgeries develop pancreatic exocrine insufficiency (PEI), which can have detrimental effects on their health. The incidence of PEI was found to be 23% after bariatric metabolic surgery and 50.4% after oesophagogastric resection, with even higher rates after certain procedures. Diagnostic testing using fecal elastase 1 was commonly utilized, and enzyme replacement therapy, when prescribed, showed positive results in 78.6% of patients. Therefore, clinicians should be vigilant in recognizing and treating PEI following non-pancreatic upper gastrointestinal surgery.

Journal Article by Hall LA, Powell-Brett S (…) Roberts KJ et 4 al. in Br J Surg

© The Author(s) 2023. Published by Oxford University Press on behalf of BJS Society Ltd. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
© The Author(s) 2023. Published by Oxford University Press on behalf of BJS Society Ltd. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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