Successful Endoscopic Submucosal Dissection for Barrett’s Neoplasia

Complete circumferential endoscopic submucosal dissection (ESD) was performed on 11 patients with early Barrett’s neoplasia in a Canadian referral center. All procedures were technically successful with en-bloc resection. Nine patients achieved clear margins, while two required esophagectomy due to positive deep margins. The final pathology revealed adenocarcinoma in seven patients, with six cases showing upstaging from initial biopsies. The median area of resected specimen was 48 cm. ESD demonstrates high procedural success and a low rate of adverse outcomes for treating multifocal dysplastic Barrett’s esophagus.