This systematic review and meta-analysis of 285 studies, including over 8 million patients, evaluated the procedure-specific risks of symptomatic venous thromboembolism (VTE) and major bleeding in general abdominal, colorectal, upper gastrointestinal, and hepatopancreatobiliary surgeries. The risk of VTE varied widely among procedures, with VTE rates ranging from <0.1% in laparoscopic cholecystectomy to 10.0% in emergency open total proctocolectomy. Thromboprophylaxis provided a net benefit in reducing VTE but was associated with a small increase in bleeding in some procedures, emphasizing the need for individualized risk prediction and patient preferences.
Journal Article by Lavikainen LI, Guyatt GH (…) Tikkinen KAO et 35 al. in Ann Surg
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