Sodium thiosulfate effectively prevents cisplatin-induced nephrotoxicity in patients undergoing cytoreductive surgery with HIPEC

Sodium thiosulfate can effectively prevent cisplatin-induced nephrotoxicity in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC), eliminating the need for preoperative intravenous hyperhydration. A retrospective analysis of 220 patients showed that the use of sodium thiosulfate significantly reduced serum creatinine levels and preserved glomerular filtration rate compared to hyperhydration alone or in combination with sodium thiosulfate. These findings have important implications for simplifying the management of patients with peritoneal metastases undergoing HIPEC with cisplatin.