Survival benefit of surgery for second primary esophageal cancer following gastrointestinal cancer is significant. Surgery, year of diagnosis, regional lymph node surgery scope, tumor differentiation grade, SEER historic stage, and triple therapy are independent prognostic factors. In a cohort study of 582 patients, surgery significantly improved survival outcomes compared to no surgery or chemoradiotherapy. These findings suggest surgery should be the main treatment for second primary esophageal cancer after gastrointestinal cancer.
Journal Article by Zhao T, Jia W, Zhao C and Wu Z in J Gastrointest Surg
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