3D imaging challenges traditional size-based classification of precancerous lesions in pancreatic ductal adenocarcinoma. Over 1400 lesions meeting size criteria for pancreatic intraepithelial neoplasia (PanIN) were identified in 3D analysis, with a quarter digitally sectioning as intraductal papillary mucinous neoplasms (IPMN). Half of these large lesions were visible on preoperative CT scans. Current classification based on 2D size assessment fails in high-resolution 3D evaluation, necessitating updated guidelines.
Journal Article by Kiemen AL, Dequiedt L (…) Hruban RH et 12 al. in Am J Surg Pathol
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.