Subscribe free

HPB & Spleen ·

Tertiary Lymphoid Structures Predict Survival in Combined Hepatocellular-Cholangiocarcinoma

High intratumoural tertiary lymphoid structure (TLS) score correlated with prolonged survival, while high TLS density in adjacent tissue indicated worse prognosis in combined hepatocellular-cholangiocarcinoma. Mature TLSS linked to favorable outcomes with more CD8+ T cell infiltration. TLSS distribution and density can predict prognosis and serve as a potential immunotherapy biomarker. CXCL12 expression in tumor tissue significantly correlated with TLS presence, indicating a promising tool for assessing treatment response.

Journal Article by Gong W, Zhang S (…) Guo H et 10 al. in Hepatol Int

© 2024. The Author(s).

read the whole article in Hepatol Int

open it in PubMed

Summaries are written to help you decide what to read. They do not replace the full paper.

Free · 5 minutes a day

Get every new paper in HPB & Spleen.

Plus the Daily Selection: the five most relevant papers of the day, each cut to its key points.

Specialty newsletters: every new paper in your field, as a list of titles linked to the source. Daily Selection: the five that matter, cut to their key points.

FreeNo spamOne-click unsubscribe

More in HPB & Spleen

The latest stitches

Surg Endosc6 Nov 2026

A new cut for robotic liver surgery

A close-to-open cutting method was used for robotic liver resection, with no bile leaks and shorter hospital stays than after laparoscopy.

Surg Endosc6 Nov 2026

Robotic bile duct stone surgery: fewer complications

Removing large common bile duct stones with a robot rather than laparoscopically was linked to fewer complications and shorter hospital stays, at a higher cost, in a study from one Chinese hospital.

All papers in HPB & Spleen →