Among 339 patients with locally advanced rectal cancer, 208 (61.3%) completed total neoadjuvant therapy, achieving a final complete response (CR) rate of 42.3%. Notably, 57 patients (27.4%) sustained clinical CR for over a year, while 42 patients showed pathologic CR post-surgery. Predictors of CR included low rectal tumor location, absence of extramural vascular invasion, and absence of mesorectal fascia involvement. Two-year disease-free survival and overall survival rates were significantly higher in patients with CR versus those with incomplete response.
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Journal Article by Erozkan K, Elamin D (…) Gorgun E et 11 al. in J Gastrointest Surg
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