A study analyzed 682 patients with locally advanced rectal cancer, revealing that 6.9% experienced local recurrence post-neoadjuvant chemoradiotherapy and total mesorectal excision. Key risk factors identified included positive circumferential resection margin, venous invasion, and perineural invasion. Among those with recurrence, 53.2% were resectable, and 65.2% of those who underwent curative resection achieved R0 status. Superior five-year survival rates were associated with R0 resections, highlighting the need for careful surveillance of high-risk patients.
Journal Article by Kim S, Huh JW (…) Shin JK et 5 al. in Eur J Surg Oncol
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