A retrospective study of 6,888 patients with gastrojejunostomy revealed a dose-dependent relationship between nonsteroidal anti-inflammatory drug (NSAID) prescriptions and the development of marginal ulcers. Among those studied, 45.2% were exposed to NSAIDs, with 10.12% developing ulcers. The odds of ulcer increased significantly with the number of NSAID exposures, from 1.67 for 1-2 prescriptions to 2.42 for over eight. Acid-suppressing therapy was identified as protective against ulcer formation.
Journal Article by Gross A, Gentle C (…) Augustin T et 4 al. in BMC Surg
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