In patients with locally advanced rectal cancer, adjuvant chemotherapy significantly reduces the risk of mortality and locoregional recurrence after neoadjuvant treatment and proctectomy. Among 746 patients studied, those with a complete total mesorectal excision (TME) showed a 73% lower risk of mortality and an 88% reduction in locoregional recurrence when receiving adjuvant chemotherapy. Noncomplete TME patients displayed similar rates of chemotherapy receipt but lacked sufficient data for recurrence analysis, suggesting a potential gap in treatment strategies.
Journal Article by Althans AR, Holder-Murray J (…) Tessler RA et 7 al. in J Surg Res
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