Sigmoid-type achalasia shows higher risk of esophageal cancer

In a study involving 450 achalasia patients undergoing peroral endoscopic myotomy (POEM), treatment outcomes were favorable across disease types, with efficacy rates of 97.9% and 94.2% at one and two years, respectively. However, the incidence of esophageal cancer varied significantly among types: 1% in straight, 2.5% in sigmoid type 1, and 10% in sigmoid type 2. Notably, there was a statistically significant trend indicating increased cancer risk with more advanced achalasia stages.