A clinical trial is set to evaluate the efficacy of oral moxifloxacin versus placebo in treating uncomplicated acute appendicitis without hospitalization. Targeting adults aged 18-60, the APPAC IV trial will assess treatment success 30 days post-discharge, aiming to determine if antibiotics and inpatient care can be safely eliminated. This noninferiority trial, conducted across nine Finnish hospitals, seeks to address a significant gap in managing appendicitis with antibiotic therapy alone.
Journal Article by Lund H, Haijanen J (…) Salminen P et 10 al. in Scand J Surg