Fatigue and Alopecia Are Key Challenges in Esophageal Cancer Treatment

In a study of 75 esophageal squamous cell carcinoma patients undergoing neoadjuvant immunochemotherapy, treatment-related adverse events (TRAEs) were better characterized over time using latent-class mixed-modeling. Most TRAEs, including pruritus, nausea, vomiting, and pain, improved, while fatigue and alopecia worsened. Patients with severe gastrointestinal TRAE trajectories had significantly poorer overall survival compared to those with mild trajectories, indicating a need for closer monitoring of these adverse effects throughout treatment.