An umbrella review of 28 articles involving over 80,000 patients reveals that extending postoperative antibiotic prophylaxis (PAP) beyond 24 hours offers no significant advantages in preventing surgical site infections compared to immediate discontinuation. The pooled risk ratio (RR) was found to be 1.07, supporting the WHO’s 2018 recommendation to cease PAP after surgical incision closure in specific procedures. Researchers emphasize the need for more studies to facilitate the effective discontinuation of PAP practices.
Systematic Review by Bwire GM, Magati RB (…) Majigo MV et 9 al. in Syst Rev
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