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Prognostic factors vary between neoadjuvant and chemo-naïve patients.

Neoadjuvant therapy changes the prognostic landscape for patients with resected pancreatic ductal adenocarcinoma (PDAC). In a study of 2,760 patients, independent predictors of overall survival (OS) differed significantly: chemotherapy-naïve patients were affected by age, CA19-9 levels, and tumor stage, while neoadjuvant therapy patients faced challenges like CA19-9 normalization and nodal presence. These insights led to online personalized prediction tools designed to enhance patient prognostication.

Journal Article by Javed AA, Habib JR (…) Daamen LA et 15 al. in Ann Surg

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