Single-cell analyses reveal significant insights into lymph node metastasis in intrahepatic cholangiocarcinoma (ICCA). A complex heterogeneity was identified within the lymph node microenvironment, with an increase in stromal and mature immune cells, particularly diverse T cell subtypes. Notably, CD36+ macrophages and SAA1+ tumor cells were implicated as critical components in the metastatic process. These findings highlight new therapeutic targets and underscore the value of single-cell technologies for advancing understanding and treatment of ICCA.
Journal Article by Li Z, Ma L (…) Hang H et 3 al. in JHEP Rep
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