Circular skin closure significantly reduces surgical site infections
A systematic review and meta-analysis revealed that circular skin closure (CSC) markedly decreases the rate of surgical site infections (SSI) following stoma closure compared to primary sutures (PS). Researchers found that only 4% of patients using CSC developed SSI, in contrast to 27% in the PS group. This analysis, which included eight randomized controlled trials with 606 patients, advocates for the adoption of CSC due to its superior outcomes in lowering SSI rates post-surgery.
Removing the rectal tumor and liver spread in one operation did not clearly raise complications or hurt survival compared with two separate operations, a French national study found.
A Japanese randomized trial found that a 14-day schedule of trifluridine-tipiracil plus bevacizumab keeps patients with metastatic colorectal cancer alive as long as the standard 28-day schedule, with far less toxicity.
