Implementing computerized provider order entry (CPOE) prompts significantly reduced the use of empiric extended-spectrum antibiotics for non-critically ill patients with abdominal infection. In a trial involving 198,480 patients across 92 hospitals, a 35% relative reduction in antibiotic days was observed with CPOE intervention compared to routine care, while hospital length of stay and ICU transfer rates remained stable. These findings suggest improved antibiotic stewardship practices can optimize treatment without compromising patient safety.
Journal Article by Gohil SK, Septimus E (…) Huang SS et 28 al. in JAMA Surg