A study involving 220 patients revealed that KRAS mutations negatively affect long-term outcomes after thermal ablation (TA) and liver resection (LR) for colorectal liver metastases (CRLM). Among patients with mutated KRAS, factors like synchronous disease and the performance of multiple TAs significantly influenced disease-free survival. Furthermore, while TA was associated with liver-only recurrences in both mutated and wild-type tumors, the risk was notably higher in mutated cases, indicating a need to tailor surgical strategies based on KRAS status.
Journal Article by Giannone F, Sangiuolo F (…) Panaro F et 8 al. in World J Surg
© 2025 The Author(s). World Journal of Surgery published by John Wiley & Sons Ltd on behalf of International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC).