Findings emphasize the importance of mismatch repair (MMR) protein expression in tumors, linking it to microsatellite instability (MSI) and its implications for colorectal and endometrial cancers. Loss of MMR status signifies potential treatment strategies for patients, helping clinicians in tailoring interventions to individual tumor profiles. This understanding may lead to improved clinical outcomes and enhance strategies for addressing DNA replication errors common in certain cancers. Insights bolster the significant utility of molecular signatures in prognosis and therapy.
Review by Nomikos IN, Kosmas C and Gkretsi V in Am J Surg
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